What genetic condition is characterized by thick tenacious mucus affecting multiple organs?

Cystic fibrosis is the genetic condition characterized by thick, tenacious mucus that affects multiple organs, particularly the lungs and digestive system. This condition arises from a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which disrupts the regulation of salt and water transport across cell membranes. As a result, the mucus produced in various organs becomes abnormally thick and sticky, leading to blockages and complications such as chronic lung infections, pancreatic insufficiency, and difficulties with nutrient absorption.

In the lungs, the accumulation of thick mucus creates an ideal environment for bacteria to thrive, resulting in persistent respiratory infections and inflammation. In the digestive system, the thick mucus can block pancreatic enzymes from reaching the intestines, leading to malnutrition and poor growth, which are hallmark concerns in children with cystic fibrosis.

Other conditions listed in the question, such as asthma and bronchiectasis, primarily involve respiratory issues, but they do not encompass the systemic effects or the specific genetic basis that defines cystic fibrosis. Respiratory distress syndrome is typically associated with premature infants and has a different etiology that does not involve thick mucus related to a genetic condition. Thus, cystic fibrosis is the correct answer due to its specific characteristics and widespread